A. Brancale

2,3-bis (phenylamino) quinoxaline - containing compounds display potent activity against Methicillin-resistant Staphylococcus aureus, Enterococcus faecalis and their biofilms

This study identifies two quinoxaline derivatives with potent antibacterial activity against MRSA, VRE, and their biofilms, showing comparable or better efficacy than existing antibiotics.

Quinoxaline-Based Anti-Schistosomal Compounds Have Potent Anti-Malarial Activity

This study identifies quinoxaline-based anti-schistosomal compounds with potent anti-malarial activity against Plasmodium falciparum, including resistance mechanisms involving pfqrp1 and pfatp2.

The Discovery of Small Molecule Inhibitors of cFLIP that Sensitise Tumour Cells to TRAIL

This paper identifies small molecule inhibitors of cFLIP that enhance TRAIL-induced apoptosis in breast cancer cells and improves their potency through structure-activity relationship studies.

Structure-Activity Relationships, Tolerability and Efficacy of Microtubule-Active 1,2,4-Triazolopyrimidines as Potential Candidates to Treat Human African Trypanosomiasis

This study evaluates the structure-activity relationships, tolerability, and efficacy of microtubule-active triazolopyrimidines against Trypanosoma brucei, identifying two congeners with significant antiparasitic effects in vivo.

Geneticin shows selective antiviral activity against SARS-CoV-2 by interfering with programmed -1 ribosomal frameshifting

This study shows geneticin inhibits SARS-CoV-2 by reducing -1 ribosomal frameshifting, effective against multiple variants in cell lines and tissue models.

Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes the hexameric complex

This study identifies fluoxetine as an inhibitor of the enterovirus 2C AAA+ ATPase, revealing its mechanism of action through structural and functional analyses.

Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) is a druggable target involved in parasite survival, oviposition and stem cell proliferation.

This study investigates the anti-schistosomal activity of HsLSD1 inhibitors on S. mansoni life cycle stages and identifies compound 33 as effective against parasite survival, oviposition, and stem cell proliferation.

The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets

This paper screens epigenetic probes/inhibitors against Schistosoma mansoni and identifies compounds targeting histone methylation/demethylation processes as potential anti-schistosomal agents.