Author

C. S. Nelson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 6 Organism:human· 4 Assay:DNA methylation· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Organism:rat· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

S. R. Permar· 7 shared A. Kaur· 3 shared H.-Y. Wang· 3 shared K. Koelle· 3 shared N. Vandergrift· 3 shared C. Chan· 2 shared D. Tran· 2 shared D. Vera Cruz· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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7 shared papersImmunology

S. R. Permar

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Relationship of maternal cytomegalovirus-specific antibody responses and viral load to vertical transmission risk following primary maternal infection in a rhesus macaque model

C. E. Otero, R. Barfield, E. Scheef, C. S. Nelson, N. Rodgers, H.-Y. Wang, M. Moström, T. D. Manuel, J. Sass, K. Schmidt, H. Taher, C. Papen, L. Sprehe, S. Kendall, A. Davalos, , S. R. Permar

This study investigates maternal cytomegalovirus (CMV) antibody responses and viral load in rhesus macaques to determine their association with vertical transmission risk, finding no link between plasma viremia or humoral responses and congenital CMV in immunocompetent dams.

PLOS Pathogens · Oct 23, 2023Peer-reviewedImmunology

Multivalent Human Cytomegalovirus Glycoprotein B Nucleoside-Modified mRNA Vaccines Demonstrate a Greater Breadth in T cell but not Antibody Responses

S. R. Permar, H.-Y. Wang, L. Li, C. S. Nelson, R. Barfield, S. Valencia, C. Chan, H. Muramatsu, P. J. C. Lin, N. Pardi, Z. An, D. Weissman

This study evaluates multivalent HCMV gB mRNA vaccines in rabbits, finding increased T cell responses but no improvement in antibody breadth.

bioRxiv · Nov 23, 2022 · PreprintImmunology

Specificity and effector functions of non-neutralizing gB-specific monoclonal antibodies isolated from healthy individuals with human cytomegalovirus infection

M. L. Goodwin, H. S. Webster, H.-Y. Wang, J. A. Jenks, C. S. Nelson, J. Tu, J. Mangold, S. Valencia, J. S. McLellan, D. Wrapp, T.-M. Fu, N. Zhang, D. Freed, D. Wang, Z. An, S. R. Permar

This study characterizes non-neutralizing gB-specific monoclonal antibodies from HCMV-infected individuals, revealing their binding specificity, genotype preference, and effector functions like ADCP and ADCC.

bioRxiv · Jan 14, 2020Immunology

High-resolution micro-epidemiology of parasite spatial and temporal dynamics in a high malaria transmission setting in Kenya

C. S. Nelson, K. M. Sumner, E. Freedman, J. W. Saelens, A. A. Obala, J. N. Mangeni, S. M. Taylor, W. P. O'Meara

The paper analyzes parasite genetic similarity in a malaria cohort to understand spatial and temporal transmission dynamics in western Kenya.

bioRxiv · Oct 9, 2019Microbiology

Impact of preexisting virus-specific maternal antibodies on cytomegalovirus population genetics in a monkey model of congenital transmission

D. Vera Cruz, C. S. Nelson, D. Tran, P. A. Barry, A. Kaur, K. Koelle, S. R. Permar

This study examines how maternal antibodies affect CMV genetic diversity in a monkey model, finding no impact on viral genetic diversity despite reduced viral load and congenital transmission.

bioRxiv · Jul 20, 2019Microbiology

Genetic signatures of human cytomegalovirus variants acquired by seronegative glycoprotein B vaccinees

C. S. Nelson, D. Vera Cruz, M. Su, G. Xie, N. Vandergrift, R. Pass, M. Forman, M. Diener-West, K. Koelle, R. Arav-Boger, S. R. Permar

This paper analyzes the genetic composition of HCMV variants in gB vaccinees and placebo recipients, finding reduced viral shedding and altered viral population dynamics in vaccinated individuals.

bioRxiv · Oct 2, 2018Microbiology

HCMV glycoprotein B subunit vaccine efficacy was mediated by non-neutralizing antibody effector functions

C. S. Nelson, T. Huffman, E. Cisneros de la Rosa, G. Xi, N. Vandergrift, R. F. Pass, J. Pollara, S. R. Permar

This paper shows that the HCMV gB/MF59 vaccine's 50% efficacy is due to non-neutralizing antibodies that mediate virion phagocytosis, not neutralization.

bioRxiv · Jan 11, 2018Immunology

Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys

C. S. Nelson, D. V. Cruz, D. Tran, K. M. Bialas, L. Stamper, H. Wu, M. Gilbert, R. Blair, X. Alvarez, H. Itell, M. Chen, A. Deshpande, F. Chiuppesi, F. Wussow, D. J. Diamond, , S. R. Permar

This study shows that preexisting antibodies can prevent congenital cytomegalovirus infection in monkeys by blocking placental transmission.

bioRxiv · Apr 15, 2017Immunology