H.-Y. Wang

Commensal bacteria inhibit viral infections via a tryptophan metabolite

The paper identifies a mechanism by which commensal bacteria inhibit viral infections through a tryptophan metabolite that activates the aryl hydrocarbon receptor.

Single-cell transcriptome landscape of zebrafish liver reveals hepatocytes and immune cell interactions in understanding nonalcoholic fatty liver disease

The paper uses single-cell RNA sequencing to map zebrafish liver cell types and interactions, identifying macrophage subtypes and their role in nonalcoholic fatty liver disease.

Comparison of Multiple Carbapenemase Tests Based on an Unbiased Colony Selection Method

This study compares carbapenemase tests using an unbiased colony selection method, finding improved detection and highlighting performance discrepancies among tests.

Functional divergence shaped the network architecture of plant immune receptors

The paper shows how functional divergence in NRC3 variants shapes the genetic architecture of the NLR network in solanaceous plants, leading to subfunctionalization and increased immune system complexity.

VviWRKY10 and VviWRKY30 co-regulate powdery mildew resistance through modulating SA and ET-based defenses in grapevine

This study shows VviWRKY10 and VviWRKY30 regulate powdery mildew resistance in grapevine by modulating SA and ET defenses, with mutual transcriptional inhibition between the two genes.

Cell Membranes Sustain Phospholipid Imbalance Via Cholesterol Asymmetry

The paper reveals that mammalian plasma membranes have phospholipid imbalances due to cholesterol asymmetry, affecting membrane permeability and protein localization.

The pentameric complex is not required for vertical transmission of cytomegalovirus in seronegative pregnant rhesus macaques

The study shows that deleting the pentameric complex in rhesus CMV does not affect congenital transmission in seronegative pregnant rhesus macaques.

Relationship of maternal cytomegalovirus-specific antibody responses and viral load to vertical transmission risk following primary maternal infection in a rhesus macaque model

This study investigates maternal cytomegalovirus (CMV) antibody responses and viral load in rhesus macaques to determine their association with vertical transmission risk, finding no link between plasma viremia or humoral responses and congenital CMV in immunocompetent dams.

Antagonistic pleiotropy plays an important role in governing the evolution and genetic diversity of SARS-CoV-2

The paper examines how antagonistic pleiotropy influences SARS-CoV-2 evolution and genetic diversity by analyzing genomic mutations and their functional impacts.

Multivalent Human Cytomegalovirus Glycoprotein B Nucleoside-Modified mRNA Vaccines Demonstrate a Greater Breadth in T cell but not Antibody Responses

This study evaluates multivalent HCMV gB mRNA vaccines in rabbits, finding increased T cell responses but no improvement in antibody breadth.

Rapid and accurate discrimination of Mycobacterium abscessus subspecies based on matrix-assisted laser desorption ionization-time of flight spectrum and machine learning

This paper develops a machine learning model using MALDI-TOF spectra to rapidly and accurately identify Mycobacterium abscessus subspecies.

Coupling of protein condensates to ordered lipid domains determines functional membrane organization

This study shows that protein condensates and lipid domains couple to organize T-cell membrane function during activation.

Targeting Reductive Metabolic Shifts by T315I Mutation in BCR-ABL Myeloid Leukemia for Therapy

This study identifies metabolic shifts in T315I-Bcr-Abl CML and shows that combining JMF4073 with UK-5099 eradicates the disease in vivo.

An E3 ligase network engages GCN1 to promote elongation factor-1α degradation on stalled ribosomes

The paper identifies an E3 ligase network that promotes eEF1A degradation on stalled ribosomes through interaction with GCN1.

Palmitoylation of PD-L1 Regulates Its Membrane Orientation and Immune Evasion

This study shows that PD-L1 palmitoylation affects its membrane orientation and immune evasion by altering its localization and interaction with PD-1 on T cells.

Signatures of adaptive evolution during human to mink SARS CoV2 cross species transmission inform estimates of the COVID19 pandemic timing

The paper analyzes SARS-CoV-2 sequences from minks and humans to determine if adaptive evolution occurred before the pandemic, suggesting the virus may have circulated in humans for at least six months prior to the Wuhan outbreak.

One viral sequence for each host? - The neglected within-host diversity as the main stage of SARS-CoV-2 evolution

The paper shows that SARS-CoV-2 exhibits substantial within-host genetic diversity, challenging the assumption of low diversity per infected individual and highlighting the importance of studying evolution within hosts.

A senescence-like cellular response inhibits bovine ephemeral fever virus proliferation

The paper shows that a senescence-like response in BHK-21 cells inhibits bovine ephemeral fever virus replication, suggesting potential strategies to modulate antiviral responses.

D614G Substitution of SARS-CoV-2 Spike Protein Increases Syncytium Formation and Viral Transmission via Enhanced Furin-mediated Spike Cleavage

This study shows the D614G substitution in SARS-CoV-2 spike protein increases viral transmission by enhancing furin-mediated cleavage, leading to more syncytium formation and higher virus titers.

Feedback inhibition of AMT1 NH4+-transporters mediated by CIPK15 kinase

This study identifies CIPK15 as a kinase that inhibits AMT1 ammonium transporters through phosphorylation, reducing NH4+ accumulation in plants.

The origin and underlying driving forces of the SARS-CoV-2 outbreak

This paper analyzes SARS-CoV-2 genetic variation and finds evidence of intergenomic recombination, relaxed selection, and possible cryptic circulation in humans before the 2020 outbreak.

Rapidly predicting vancomycin resistance of Enterococcus faecium through MALDI-TOF MS spectra obtained in real-world clinical microbiology laboratory

This study develops a machine learning algorithm using MALDI-TOF MS spectra to rapidly and accurately predict vancomycin resistance in Enterococcus faecium isolates, improving antibiotic use accuracy by 30%.

Specificity and effector functions of non-neutralizing gB-specific monoclonal antibodies isolated from healthy individuals with human cytomegalovirus infection

This study characterizes non-neutralizing gB-specific monoclonal antibodies from HCMV-infected individuals, revealing their binding specificity, genotype preference, and effector functions like ADCP and ADCC.

Circular RNAs regulate cancer stem cells by FMRP against CCAR1 complex in hepatocellular carcinoma

This study identifies circZKSCAN1 as a negative regulator of cancer stem cells in hepatocellular carcinoma, revealing its mechanism through interaction with FMRP and CCAR1-Wnt signaling.

Genetic load and mutational meltdown in cancer cell populations

The paper studies mutational meltdown in HeLa cancer cell populations, finding high rates of deleterious copy number variations and significant fitness reduction per mutation.