Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation
G. Montoya, P. Mesa, S. Garcia, L. de la Puente, G. Aizpurua, M. Barbacid, M. d. c. G. Lechuga, E. Zarzuela, C. Santiveri, M. Sanclemente, J. Munoz, R. Campos-Olivas, J. Martinez-Torrecuadrada, M. Muesteanu
The paper determines the structure of the RAF1-HSP90-CDC37 complex using cryo-EM, revealing how CDC37 regulates RAF1 and potential therapeutic targets.
bioRxiv · May 4, 2022Biochemistry