A cell cycle kinase-phosphatase module restrains PI3K-Akt activity in an mTORC1-dependent manner
B. Sanz-Castillo, B. Hurtado, A. El Bakkali, D. Hermida, B. Salvador-Barbero, D. Martinez-Alonso, J. Gonzalez-Martinez, C. Santiveri, R. Campos-Oliva, P. Ximenez, J. Munoz, M. Alvarez-Fernandez, M. Malumbres
This study identifies a cell cycle kinase-phosphatase module that restrains PI3K-Akt activity through mTORC1-dependent phosphorylation of IRS1 and GRB10.
bioRxiv · Nov 26, 2020 · PreprintCell Biology