Author

M. Barbacid

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. Fernandez· 1 shared C. Martins· 1 shared C. Santiveri· 1 shared D. M. Rassl· 1 shared D. Macias· 1 shared D. Munoz-Espin· 1 shared D. Santamaria· 1 shared D. Veroutis· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperCancer Biology

A. Fernandez

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A tumour-promoting senescent secretome triggered by platinum chemotherapy exploits a targetable TGFβR1/Akt-mTOR axis in lung cancer

E. Gonzalez-Gualda, D. Macias, S. Morsli, E. Martin, H.-L. Ou, M. Denholm, I. Olan, R. Hoffmann, M. Dane, D. Veroutis, G. Medrano, F. Mulero, C. Martins, M. Barbacid, V. Gorgoulis, , D. Munoz-Espin

This study shows platinum chemotherapy induces a senescent secretome in lung cancer that promotes tumor growth via the TGFβR1/Akt-mTOR axis, and targeting this pathway reduces tumor burden.

bioRxiv · Aug 1, 2022 · PreprintCancer Biology

Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation

G. Montoya, P. Mesa, S. Garcia, L. de la Puente, G. Aizpurua, M. Barbacid, M. d. c. G. Lechuga, E. Zarzuela, C. Santiveri, M. Sanclemente, J. Munoz, R. Campos-Olivas, J. Martinez-Torrecuadrada, M. Muesteanu

The paper determines the structure of the RAF1-HSP90-CDC37 complex using cryo-EM, revealing how CDC37 regulates RAF1 and potential therapeutic targets.

bioRxiv · May 4, 2022Biochemistry

Myc stimulates cell cycle progression through the activation of Cdk1 and phosphorylation of p27

J. Leon, L. Garcia-Gutierrez, G. Bretones, E. Molina, I. Arechaga, J. C. R. Acosta, R. Blanco, A. Fernandez, L. Alonso, P. Sicinski, M. Barbacid, D. Santamaria

The paper shows Myc activates Cdk1 to phosphorylate p27 at Thr187, promoting its degradation and cell cycle progression, with Cdk1 inhibition causing synthetic lethality with Myc.

bioRxiv · Dec 16, 2018Cancer Biology