Sphingosine-1-phosphate signaling inhibition suppresses Th1-like Treg generation by reversing mitochondrial uncoupling
R. Coulombeau, C. Selck, N. Giang, A. Al-Mohammad, N. Ng, A. K. Maher, R. Arguello, A. Scalfari, J. Varley, R. Nicholas, M. Dominguez-Villar
This study shows that inhibiting S1P signaling with FTY720 suppresses Th1-like Treg generation and restores their suppressive function by reversing mitochondrial uncoupling.
bioRxiv · May 20, 2024 · PreprintImmunology