Author

A. Kallies

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

A. Barugahare· 1 shared A. E. Morey· 1 shared A. Garnham· 1 shared A. Odainic· 1 shared A. Pfefferle· 1 shared A. T. Papenfuss· 1 shared A. W. Goldrath· 1 shared B. E. Russ· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperImmunology

A. Barugahare

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

IL-2 enhances effector function but suppresses follicular localization of CD8+ T cells in chronic infection

Y. Chen, P. Zhou, P. M. Gubser, Y. A. Leong, J. He, Y. Wei, F. V. Makota, M. Pazhouhandeh, T. Zheng, J. Yunis, Z. Li, A. Kallies, D. Yu

This study shows IL-2 enhances CD8+ T cell effector function but inhibits CXCR5+ TPEX cell formation and follicular infection control in chronic LCMV infection.

bioRxiv · May 2, 2024 · PreprintImmunology

A multi-organ map of the human immune system across age, sex and ethnicity

S. Mangiola, M. Milton, N. Ranathunga, C. LiWaiSuen, A. Odainic, E. Yang, W. Hutchison, A. Garnham, J. Iskander, B. Pal, V. J. Yadav, F. Rossello, V. Carey, A. Kallies, S. Bedoui, , A. T. Papenfuss

The paper creates a comprehensive immune system map across age, sex, and ethnicity using single-cell RNA sequencing data, revealing immune ageing patterns and ethnic diversity in immune checkpoints.

bioRxiv · Jun 8, 2023 · PreprintImmunology

Active maintenance of CD8+ T cell naivety through regulation of global genome architecture

B. E. Russ, K. Tsyganov, S. Quon, B. Yu, J. Li, J. K. Lee, M. Olshansky, Z. He, P. F. Harrison, A. Barugahare, M. See, S. Nuessing, A. E. Morey, V. A. Udupa, T. J. Bennett, , S. J. Turner

This study shows that transcription factors maintain CD8+ T cell naivety by enforcing a distinct chromatin architecture that remodels upon activation.

bioRxiv · Feb 26, 2023 · PreprintImmunology

Extra-islet expression of islet antigen boosts T-cell exhaustion to prevent autoimmune diabetes

C. Selck, G. Jhala, D. De George, C.-T. J. Kwong, M. K. Christensen, E. Pappas, X. Liu, T. Ge, P. Trivedi, A. Kallies, H. Thomas, T. W. H. Kay, B. Krishnamurthy

This study shows that extra-islet antigen exposure leads to T-cell exhaustion, which prevents autoimmune diabetes in NOD mice.

bioRxiv · Feb 12, 2023 · PreprintImmunology

The ratio of exhausted to resident infiltrating lymphocytes is prognostic for colorectal cancer patient outcome

M. Foroutan, R. Molania, A. Pfefferle, C. Behrenbruch, A. Kallies, T. P. Speed, J. Cursons, N. D. Huntington

This study identifies signatures of lymphocyte residency and exhaustion in colorectal cancer using single-cell RNA-seq and shows their association with patient survival outcomes.

bioRxiv · Dec 19, 2020Cancer Biology