Genetic depletion studies define receptor usage by virulent hantaviruses in human endothelial cells
M. E. Dieterle, C. Sola-Riera, R. K. Jangra, C. Ye, S. M. Goodfellow, E. Mittler, E. Kasikci, S. B. Bradfute, J. Klingström, K. Chandran
This study uses CRISPR/Cas9 to knock out potential hantavirus receptors in human endothelial cells, finding that PCDH1 is critical for some hantaviruses while other receptors like integrins and DAF are not essential.
bioRxiv · Dec 30, 2020Microbiology