R. K. Jangra

Two point mutations in protocadherin-1 disrupt Andes hantavirus recognition and afford protection against lethal infection

The paper identifies two point mutations in PCDH1 that disrupt ANDV recognition and protect against lethal infection in Syrian hamsters.

A combination of RBD and NTD neutralizing antibodies limits the generation of SARS-CoV-2 spike neutralization-escape mutants

This paper identifies NTD-targeting neutralizing antibodies and shows that combining RBD and NTD antibodies reduces the emergence of neutralization-escape mutants.

A glycoprotein mutation that emerged during the 2013-2016 Ebola virus epidemic alters proteolysis and accelerates membrane fusion

This paper investigates how the A82V mutation in the Ebola virus glycoprotein enhances infectivity by altering proteolysis and accelerating membrane fusion.

Genetic depletion studies define receptor usage by virulent hantaviruses in human endothelial cells

This study uses CRISPR/Cas9 to knock out potential hantavirus receptors in human endothelial cells, finding that PCDH1 is critical for some hantaviruses while other receptors like integrins and DAF are not essential.

Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis

This study evaluates the production, characterization, and antigenicity of SARS-CoV-2 S protein constructs in two cell lines, showing high-quality yields and consistent behavior across assays.

A replication-competent vesicular stomatitis virus for studies of SARS-CoV-2 spike-mediated cell entry and its inhibition

This paper develops a recombinant vesicular stomatitis virus expressing SARS-CoV-2 spike protein to assess neutralizing antibodies in convalescent sera and validate its utility for vaccine and therapeutic development.

Broad sarbecovirus neutralizing antibodies define a key site of vulnerability on the SARS-CoV-2 spike protein

The paper identifies broadly neutralizing antibodies against SARS-CoV-2 and related sarbecoviruses, highlighting a conserved epitope on the spike protein as a potential vaccine target.

Direct intracellular visualization of Ebola virus-receptor interaction by in situ proximity ligation

This paper introduces an in situ proximity ligation assay to visualize Ebola virus glycoprotein (GPCL) interaction with the receptor NPC1 in infected cells, revealing insights into viral entry mechanisms and drug inhibition.

A virion-based assay for glycoprotein thermostability reveals key determinants of filovirus entry and its inhibition

This paper introduces an ELISA-based assay to measure the thermostability of filovirus glycoproteins, revealing how proteolytic cleavage, acid pH, and small-molecule inhibitors affect GP stability and viral entry.

Human antibody cocktail deploys multiple functions to confer pan-ebolavirus protection

This paper develops a human antibody cocktail, MBP134, that provides broad protection against multiple ebolaviruses, showing enhanced efficacy in guinea pigs compared to individual antibodies.

Two point mutations in the Hantaan virus glycoproteins afford the generation of a highly infectious recombinant vesicular stomatitis virus vector

This paper identifies two point mutations in Hantaan virus glycoproteins that enhance their incorporation into recombinant VSV particles, enabling the generation of a highly infectious rVSV vector for hantavirus research.