Author

M. E. Dieterle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 5 Approach:experimental assay· 4 Organism:human· 4 Assay:proteomics· 3 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

K. Chandran· 5 shared R. K. Jangra· 5 shared C. Florez· 4 shared D. Haslwanter· 4 shared E. Laudermilch· 4 shared J. M. Fels· 4 shared A. Mengotto· 3 shared A. S. Herbert· 3 shared

Activity by Year

2020-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersMicrobiology

K. Chandran

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Author profile →

5 papers

Recent·Most cited

A combination of RBD and NTD neutralizing antibodies limits the generation of SARS-CoV-2 spike neutralization-escape mutants

D. Haslwanter, M. E. Dieterle, A. Z. Wec, C. M. O'Brien, M. Sakharkar, C. Florez, K. Tong, C. G. Rappazzo, G. Lasso, O. Vergnolle, A. S. Wirchnianski, R. H. Bortz, E. Laudermilch, J. M. Fels, A. Mengotto, , R. K. Jangra

This paper identifies NTD-targeting neutralizing antibodies and shows that combining RBD and NTD antibodies reduces the emergence of neutralization-escape mutants.

mBio · Oct 26, 2021Peer-reviewedMicrobiology

Genetic depletion studies define receptor usage by virulent hantaviruses in human endothelial cells

M. E. Dieterle, C. Sola-Riera, R. K. Jangra, C. Ye, S. M. Goodfellow, E. Mittler, E. Kasikci, S. B. Bradfute, J. Klingström, K. Chandran

This study uses CRISPR/Cas9 to knock out potential hantavirus receptors in human endothelial cells, finding that PCDH1 is critical for some hantaviruses while other receptors like integrins and DAF are not essential.

bioRxiv · Dec 30, 2020Microbiology

Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis

N. G. Herrera, N. C. Morano, A. Celikgil, G. I. Georgiev, R. J. Malonis, J. H. Lee, K. Tong, O. Vergnolle, A. B. Massimi, L. Y. Yen, A. J. Noble, M. Kopylov, J. B. Bonanno, S. C. Garrett-Thomson, D. B. Hayes, , S. C. Almo

This study evaluates the production, characterization, and antigenicity of SARS-CoV-2 S protein constructs in two cell lines, showing high-quality yields and consistent behavior across assays.

bioRxiv · Jun 14, 2020Biochemistry

A replication-competent vesicular stomatitis virus for studies of SARS-CoV-2 spike-mediated cell entry and its inhibition

M. E. Dieterle, D. Haslwanter, R. H. Bortz, A. S. Wirchnianski, G. Lasso, O. Vergnolle, S. A. Abbasi, J. M. Fels, E. Laudermilch, C. Florez, A. Mengotto, D. Kimmel, R. J. Malonis, G. Georgiev, J. Quiroz, , R. K. Jangra

This paper develops a recombinant vesicular stomatitis virus expressing SARS-CoV-2 spike protein to assess neutralizing antibodies in convalescent sera and validate its utility for vaccine and therapeutic development.

bioRxiv · May 20, 2020Microbiology

Broad sarbecovirus neutralizing antibodies define a key site of vulnerability on the SARS-CoV-2 spike protein

A. Z. Wec, D. Wrapp, A. S. Herbert, D. P. Maurer, D. Haslwanter, M. Sakharkar, R. K. Jangra, M. E. Dieterle, A. Lilov, D. Huang, L. V. Tse, N. V. Johnson, C.-L. Hsieh, N. Wang, J. H. Nett, , L. M. Walker

The paper identifies broadly neutralizing antibodies against SARS-CoV-2 and related sarbecoviruses, highlighting a conserved epitope on the spike protein as a potential vaccine target.

bioRxiv · May 15, 2020 · PreprintImmunology