Author

T. M. Handel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Pharmacology & Toxicology· 2 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

I. Kufareva· 3 shared B. S. Stephens· 2 shared C. Salanga· 2 shared C. T. Schafer· 2 shared M. Gustavsson· 2 shared T. Ngo· 2 shared A. J. Ridley· 1 shared A. J. Tebben· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersPharmacology & Toxicology

I. Kufareva

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Molecular determinants of antagonist interactions with chemokine receptors CCR2 and CCR5

J. R. D. Dawson, G. M. Wadman, P. Zhang, A. J. Tebben, P. H. Carter, S. Gu, T. Shroka, L. Borrega-Roman, C. Salanga, T. M. Handel, I. Kufareva

This study identifies molecular determinants of CCR2 and CCR5 antagonist interactions using docking and AI screening, revealing structural principles and selectivity mechanisms.

bioRxiv · Nov 15, 2023 · PreprintPharmacology & Toxicology

Distinct Activation Mechanisms of CXCR4 and ACKR3 Revealed by Single-Molecule Analysis of their Conformational Landscapes

C. T. Schafer, R. F. Pauszek, M. Gustavsson, T. M. Handel, D. P. Millar

This study uses single-molecule FRET to compare conformational dynamics of CXCR4 and ACKR3, revealing distinct activation mechanisms and conformational landscapes.

bioRxiv · Oct 31, 2023Biophysics

Atypical Chemokine Receptor 3 'Senses' CXC Chemokine Receptor 4 Activation Through GPCR Kinase Phosphorylation

C. T. Schafer, Q. Chen, J. J. G. Tesmer, T. M. Handel

This study shows that ACKR3 senses CXCR4 activation via GRK2-dependent phosphorylation, with GRK5 playing a dominant role in {beta}-arrestin recruitment and chemokine scavenging.

bioRxiv · Feb 25, 2023Biochemistry

Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate wide-spread non-receptor mediated immune cell recruitment

A. L. Gray, R. Karlsson, A. R. Roberts, A. J. Ridley, N. Pun, C. Hughes, L. Medina-Ruiz, H. Birchenough, C. Salanga, E. A. Yates, J. E. Turnbull, T. M. Handel, G. Graham, T. A. Jowitt, I. Schiessl, , D. P. Dyer

The paper shows CXCL4 binds to extracellular matrix proteoglycans, increasing vascular permeability and recruiting various leukocytes through a non-canonical mechanism.

bioRxiv · Jul 10, 2022 · PreprintImmunology

Functional anatomy of the full length CXCR4-CXCL12 complex systematically dissected by quantitative model-guided mutagenesis

B. S. Stephens, T. Ngo, I. Kufareva, T. M. Handel

A systematic structure-guided mutagenesis study of chemokine receptor CXCR4 reveals novel insights into epitopes regulating ligand recognition, ligand specificity and CXCL12-mediated signaling.

bioRxiv · Jan 21, 2020Pharmacology & Toxicology

Crosslinking-guided geometry of a complete CXC receptor-chemokine complex and the basis of chemokine subfamily selectivity

T. Ngo, B. S. Stephens, M. Gustavsson, L. G. Holden, R. Abagyan, T. M. Handel, I. Kufareva

This paper determines the structure of the CXCR4-CXCL12 complex using crosslinking, revealing the geometry and selectivity determinants of CXC receptor-chemokine interactions.

bioRxiv · Jan 10, 2020Biochemistry