Author

V. Vasiliou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Immunology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Assay:metabolomics· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Y. Chen· 5 shared D. Brenner· 2 shared D. C. Thompson· 2 shared D. J. Orlicky· 2 shared G. Charkoftaki· 2 shared I. S. Harris· 2 shared R. Garcia-Milian· 2 shared V. Mironova· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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5 shared papersImmunology

Y. Chen

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation

L. Bonetti, V. Horkova, J. Longworth, L. Guerra, H. Kurniawan, D. G. Franchina, L. Soriano-Baguet, M. Grusdat, S. Spath, E. Koncina, A. Ewen, C. Binsfeld, C. Verscheuren, J.-J. Gerardy, T. Kobayashi, , D. Brenner

This study identifies a Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis that protects against intestinal inflammation by maintaining barrier integrity and preventing mortality from C. rodentium infection.

bioRxiv · Jul 6, 2023Immunology

Endocrine pancreas-specific Gclc gene deletion causes a severe diabetes phenotype

E. A. Davidson, Y. Chen, S. Singh, D. J. Orlicky, B. Thompson, Y. Wang, G. Charkoftaki, T. Furnary, R. L. Cardone, R. G. Kibbey, C. T. Shearn, D. W. Nebert, D. C. Thompson, V. Vasiliou

This study shows that deleting the Gclc gene in the endocrine pancreas of mice leads to severe diabetes due to oxidative stress and islet dysfunction.

bioRxiv · Jun 13, 2023 · PreprintPhysiology

Glutathione supports lipid abundance in vivo

G. Asantewaa, E. T. Tuttle, N. P. Ward, Y. P. Kang, Y. Kim, M. E. Kavanagh, N. Girnius, Y. Chen, R. Duncan, K. Rodriguez, F. Hecht, M. Zocchi, L. Smorodintsev-Schiller, T. Q. Scales, K. Taylor, , I. S. Harris

This study shows that glutathione (GSH) is essential for lipid abundance in adult tissues, particularly in the liver, by repressing NRF2.

bioRxiv · Feb 10, 2023 · PreprintBiochemistry

Novel insights into the mode of action of 1,4-dioxane using a systems screening approach

V. Vasiliou, G. Charkoftaki, J. P. Golla, A. Santos-Neto, D. J. Orlicky, R. Garcia-Milian, Y. Chen, N. J. W. Rattray, Y. Cai, Y. Wang, C. T. Shern, V. Mironova, Y. Wang, C. H. Johnson, D. C. Thompson

This study investigates the toxic effects of 1,4-dioxane in mice using histopathology and multi-omics approaches, finding DNA damage counterbalanced by repair mechanisms with no systemic metabolic impact.

bioRxiv · Dec 27, 2020 · PreprintPharmacology & Toxicology

Molecular pathway analysis indicates a distinct metabolic and immune phenotype in women with right-sided colon cancer

C. Johnson, Y. Sun, V. Mironova, Y. Chen, E. P. F. Lundh, Q. Zhang, Y. Cai, V. Vasiliou, Y. Zhang, R. Garcia-Milian, S. A. Khan

This study identifies a distinct metabolic and immune phenotype in women with right-sided colon cancer through gene expression analysis of public datasets.

bioRxiv · Jun 4, 2019Cell Biology