Tuning TPO-R signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia
L. Cui, I. Moraga, T. Lerbs, C. V. Neste, S. Wilmes, N. Tsutsumi, A. C. Trotman-Grant, M. Gakovic, S. Andrews, J. Gotlib, S. Darmanis, M. Enge, S. Quake, I. S. Hitchcock, J. Piehler, , G. Wernig
This study develops diabody ligands that modulate TPO-R signaling, showing partial agonists preserve HSCs and inhibit ET oncogenesis.
bioRxiv · Sep 23, 2020Cell Biology