Author

N. Tsutsumi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Biophysics· 1 Cell Biology· 1 Immunology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:protein structure prediction· 3 Assay:cryo-EM· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

K. C. Garcia· 3 shared N. A. Caveney· 3 shared C. R. Glassman· 2 shared K. M. Jude· 2 shared A. C. Trotman-Grant· 1 shared A. Nishimura· 1 shared C. Garcia· 1 shared C. V. Neste· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

K. C. Garcia

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Structural insight into guanylyl cyclase receptor hijacking of the kinase-Hsp90 regulatory mechanism

N. A. Caveney, N. Tsutsumi, K. C. Garcia

This study presents the cryo-EM structure of GC-C with Hsp90 and Cdc37, revealing how membrane receptor guanylyl cyclases use kinase-like Hsp90 regulatory mechanisms and informing therapeutic development.

bioRxiv · Feb 14, 2023Biochemistry

Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for co-receptor discrimination

N. Tsutsumi, S. Hwang, S. Hansen, D. Waghray, N. Wang, Y. Miao, C. R. Glassman, N. A. Caveney, K. M. Jude, C. Y. Janda, R. Hannoush, K. C. Garcia

The paper determines the structure of a ternary Wnt-Frizzled-LRP6 complex, revealing how co-receptor discrimination occurs through specific domains.

bioRxiv · Oct 21, 2022Biophysics

Structure of the IL-27 quaternary receptor signaling complex

N. A. Caveney, C. R. Glassman, K. M. Jude, N. Tsutsumi, K. C. Garcia

The paper determines the structure of the IL-27 receptor signaling complex using cryo-EM, revealing a unique three-site assembly mechanism distinct from related cytokines.

bioRxiv · Mar 8, 2022Immunology

DOMINANT AWN INHIBITOR encodes the ALOG protein originating from gene duplication and inhibits awn elongation by suppressing cell proliferation and elongation in sorghum

H. Takanashi, H. Kajiya-Kanegae, A. Nishimura, J. Yamada, m. Ishimori, M. Kobayashi, K. Yano, H. Iwata, N. Tsutsumi, W. Sakamoto

This study identifies DAI, a dominant awn inhibitor in sorghum, which originated from gene duplication and suppresses awn elongation by inhibiting cell proliferation and elongation.

bioRxiv · Sep 29, 2021Plant Biology

Tuning TPO-R signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia

L. Cui, I. Moraga, T. Lerbs, C. V. Neste, S. Wilmes, N. Tsutsumi, A. C. Trotman-Grant, M. Gakovic, S. Andrews, J. Gotlib, S. Darmanis, M. Enge, S. Quake, I. S. Hitchcock, J. Piehler, , G. Wernig

This study develops diabody ligands that modulate TPO-R signaling, showing partial agonists preserve HSCs and inhibit ET oncogenesis.

bioRxiv · Sep 23, 2020Cell Biology