Author

S. Wilmes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

I. Moraga· 4 shared J. Piehler· 3 shared A. Cozzani· 2 shared E. Pohler· 2 shared S. MITRA· 2 shared A. C. Trotman-Grant· 1 shared C. FERRAND· 1 shared C. Garbers· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersImmunology

I. Moraga

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structural insights into the assembly and activation of IL-27 signalling complex

Y. Jin, P. K. Fyfe, S. Gardner, S. Wilmes, D. Bubeck, I. Moraga

This study determines the structure of the IL-27 receptor recognition complex using cryoEM, revealing how IL-27 bridges IL-27R and GP130 to initiate signaling.

bioRxiv · Feb 18, 2022 · PreprintImmunology

Tuning TPO-R signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia

L. Cui, I. Moraga, T. Lerbs, C. V. Neste, S. Wilmes, N. Tsutsumi, A. C. Trotman-Grant, M. Gakovic, S. Andrews, J. Gotlib, S. Darmanis, M. Enge, S. Quake, I. S. Hitchcock, J. Piehler, , G. Wernig

This study develops diabody ligands that modulate TPO-R signaling, showing partial agonists preserve HSCs and inhibit ET oncogenesis.

bioRxiv · Sep 23, 2020Cell Biology

Engineered IL-10 variants elicit potent immuno-modulatory activities at therapeutic low ligand doses

C. Gorby, J. Sotolongo Bellon, S. Wilmes, W. Warda, E. Pohler, P. Fyfe, A. Cozzani, C. FERRAND, M. Walter, S. MITRA, J. Piehler, I. Moraga

This study engineered IL-10 variants with enhanced receptor affinity, showing improved bioactivity and gene expression at lower doses in human monocytes and CD8 T cells.

bioRxiv · Mar 10, 2020Immunology

Kinetics of cytokine receptor trafficking determine signaling and functional selectivity

J. Martinez-Fabregas, S. Wilmes, L. Wang, M. Hafer, E. Pohler, J. Lokau, C. Garbers, A. Cozzani, J. Piehler, M. Kazemian, S. Mitra, I. Moraga

The paper investigates how cytokine receptor binding kinetics affect signaling outcomes by engineering IL-6 variants with different affinities to gp130.

bioRxiv · May 16, 2019Immunology