I. Moraga

Differential functional coupling in Gp130-JAK complexes expands the plasticity of the interleukin-6 signaling axis

The paper investigates how different JAKs in Gp130 signaling complexes lead to distinct STAT activation profiles and signaling outcomes.

Structural insights into the assembly and activation of IL-27 signalling complex

This study determines the structure of the IL-27 receptor recognition complex using cryoEM, revealing how IL-27 bridges IL-27R and GP130 to initiate signaling.

Tuning TPO-R signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia

This study develops diabody ligands that modulate TPO-R signaling, showing partial agonists preserve HSCs and inhibit ET oncogenesis.

CDK8 fine-tunes IL-6 transcriptional activities by limiting STAT3 resident time at the gene loci

The paper identifies CDK8 as a negative regulator of STAT3 transcriptional activity in Th-1 cells, showing it limits STAT3's resident time at gene loci, thereby modulating IL-6 responses.

Engineered IL-10 variants elicit potent immuno-modulatory activities at therapeutic low ligand doses

This study engineered IL-10 variants with enhanced receptor affinity, showing improved bioactivity and gene expression at lower doses in human monocytes and CD8 T cells.

Kinetics of cytokine receptor trafficking determine signaling and functional selectivity

The paper investigates how cytokine receptor binding kinetics affect signaling outcomes by engineering IL-6 variants with different affinities to gp130.

Loss of Adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22

This study shows that loss of Apc function in intestinal epithelial cells reduces IL-22 receptor expression and STAT3 activation, leading to resistance to IL-22 and increased genetic instability.