S. Darmanis

Glomerular immune injury promotes anti-tumor activity

This study shows that glomerular immune injury increases anti-tumor activity by altering bone marrow transcription in mice.

Aging and senescence-associated analysis of the aged kidney glomerulus highlights the role of mesangial cells in renal aging

The paper analyzes aging and senescence in kidney glomeruli using bulk and single-cell RNA sequencing, identifying mesangial cells as key contributors to age-related renal dysfunction.

The renal capsule, a vibrant and adaptive cell environment of the kidney in homeostasis and aging

This study characterizes the renal capsule's cellular composition and dynamics in health, aging, and disease, revealing its adaptive responses and age-related changes.

Dissecting the contributions of tumor heterogeneity on metastasis at single-cell resolution

This study analyzes single-cell transcriptomes of primary tumors and metastases from breast cancer models, identifying transcriptional differences and gene signatures linked to metastatic potential and patient outcomes.

Human melanocyte development and melanoma dedifferentiation at single cell resolution

This study characterizes human melanocyte development and dedifferentiation using single-cell RNA-sequencing, identifying site-specific subpopulations and transcriptional programs distinct from model systems.

Tuning TPO-R signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia

This study develops diabody ligands that modulate TPO-R signaling, showing partial agonists preserve HSCs and inhibit ET oncogenesis.

Ageing compromises mouse thymus function and remodels epithelial cell differentiation

This study investigates how ageing affects mouse thymus function, revealing that progenitor cell differentiation is disrupted, leading to impaired T cell selection and self-antigen representation.

A Single Cell Transcriptomic Atlas Characterizes Aging Tissues in the Mouse

This study creates a single cell transcriptomic atlas of aging mouse tissues, identifying age-related changes in cell types and organ composition across 23 tissues.

Heterogeneity and targeted therapy-induced adaptations in lung cancer revealed by longitudinal single-cell RNA sequencing

This study uses longitudinal single-cell RNA sequencing to reveal therapy-induced adaptations in lung cancer, identifying cell state transitions and pathways associated with treatment response and resistance.

Human IgE producing B cells have a unique transcriptional program and generate high affinity, allergen-specific antibodies

The paper isolates and characterizes IgE-producing B cells from allergic individuals using scRNA-seq, revealing unique transcriptional features, high-affinity antibodies, and convergent evolution in allergen specificity.