Author

E. Colombo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

A. Bolleboom· 1 shared A. Loffreda· 1 shared A. Paini· 1 shared B. B. Oude Munnink· 1 shared B. E. Verstrepen· 1 shared C. Dirven· 1 shared C. Tacchetti· 1 shared C. W. E. Embregts· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperMicrobiology

A. Bolleboom

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

NPMc+ and Flt3-ITD cooperation promotes a new oncogenic HSC state that supports transformation and leukemia stem cell maintenance

E. Colombo

This study shows that NPMc+ and Flt3-ITD cooperate to create a new quiescent HSC state that supports leukemia transformation and stem cell maintenance.

bioRxiv · Jul 25, 2024 · PreprintCancer Biology

Systematic Evaluation of High-Throughput PBK Modelling Strategies for the Prediction of Intravenous and Oral Pharmacokinetics in Humans

R. Geci, D. Gadaleta, M. Garcia de Lomana, R. Ortega-Vallbona, E. Colombo, E. Serrano-Candelas, A. Paini, L. Kuepfer, S. Schaller

This study evaluates high-throughput PBK modelling strategies for predicting human intravenous and oral pharmacokinetics using in vitro and in silico data.

bioRxiv · Mar 20, 2024Pharmacology & Toxicology

Dissecting MPXV neurotropism and host antiviral signaling using human stem cell-based models

L. Bauer, S. Giussani, N. Palazzi, E. Bot, E. Colombo, F. Zare, F. Pinci, L. Leijten, K. Lanko, F. F. W. Benavides, H. Smeenk, C. W. E. Embregts, J. K. H. Spoor, C. Dirven, Z. Gao, , O. Harschnitz

This study investigates MPXV neurotropism and antiviral signaling in CNS cells using human stem cell-derived models, finding that glial cells are more susceptible and exhibit reduced type I IFN responses.

bioRxiv · Aug 25, 2023 · PreprintMicrobiology

Chromatin organization drives the exploration strategy of nuclear factors

M. Mazzocca, A. Loffreda, E. Colombo, T. Fillot, D. Gnani, P. Falletta, E. Monteleone, S. Capozi, E. Bertrand, G. Legube, Z. Lavagnino, C. Tacchetti, D. Mazza

This study shows how nuclear factors explore chromatin by balancing diffusion and dense region sampling, with implications for p53 function and nuclear organization.

bioRxiv · Dec 29, 2022 · PreprintBiophysics