L. Leijten

Dissecting MPXV neurotropism and host antiviral signaling using human stem cell-based models

This study investigates MPXV neurotropism and antiviral signaling in CNS cells using human stem cell-derived models, finding that glial cells are more susceptible and exhibit reduced type I IFN responses.

The pro-inflammatory response to influenza A virus infection is fueled by endothelial cells

This study shows that endothelial cells are abortively infected by influenza A virus and contribute to systemic inflammation through increased cytokine secretion in co-cultures with infected epithelial cells.

Differences in neuroinflammation in the olfactory bulb between D614G, Delta and Omicron BA.1 SARS-CoV-2 variants in the hamster model

The paper compares neuroinflammation in the olfactory bulb of hamsters infected with D614G, Delta, and Omicron BA.1 SARS-CoV-2 variants, finding differences in neuroinvasion and neurovirulence.

Actinosomes: condensate-templated proteinaceous containers for engineering synthetic cells

This paper introduces actinosomes, proteinaceous containers formed via biomolecular condensates and actin polymerization, demonstrating their use as bioreactors for protein synthesis.

Replication kinetic, cell tropism and associated immune responses in SARS-CoV-2 and H5N1 virus infected human iPSC derived neural models

This study compares SARS-CoV-2 and H5N1 virus replication, cell tropism, and immune responses in human iPSC-derived neural cultures, finding sparse SARS-CoV-2 infection with immune activation versus efficient H5N1 replication.

Comparative Pathogenesis Of COVID-19, MERS And SARS In A Non-Human Primate Model

This study compares the pathogenesis of SARS-CoV-2, MERS-CoV, and SARS-CoV in non-human primates, showing SARS-CoV-2 causes a COVID-19-like disease with prolonged viral excretion without clinical signs.