Focused ultrasound-mediated brain genome editing
Y.-H. Lao, R. Ji, J. K. Zhou, K. J. Snow, N. Kwon, E. Saville, S. He, S. Chauhan, C.-W. Chi, M. S. Datta, H. Zhang, C. H. Quek, S. Cai, M. Li, Y. Gaitan, , K. W. Leong
This paper demonstrates a method to edit the brain genome in mammals using focused ultrasound to temporarily open the blood-brain barrier for CRISPR/Cas9 delivery via intravenous injection.
bioRxiv · Dec 10, 2022Bioengineering