R. Ji

The under-recognized dominance of magnetosome gene cluster-containing bacteria in oxygen-stratified freshwater ecosystems

The paper identifies a high abundance of magnetosome gene cluster-containing bacteria in oxygen-stratified freshwater environments, revealing Deltaproteobacteria as dominant rather than Magnetococcia.

Logic Gate Activated Lysosome Targeting DNA Nanodevice for Controlled Proteins Degradation

This paper develops a logic-gate activated lysosome targeting DNA nanodevice for controlled protein degradation and modulates T cell-mediated antitumor immunity.

Characterization and contribution of RPE senescence to Age-related macular degeneration in Tnfrsf10 knock out mice

This study investigates how RPE senescence contributes to AMD using TNFRSF10A silenced hRPE cells and Tnfrsf10 KO mice, showing increased p16 and p21 expression and metabolic changes.

Focused ultrasound-mediated brain genome editing

This paper demonstrates a method to edit the brain genome in mammals using focused ultrasound to temporarily open the blood-brain barrier for CRISPR/Cas9 delivery via intravenous injection.

N-terminal Domain Influences Steroid Activation of the Atlantic Sea Lamprey Corticoid Receptor

This study identifies and characterizes the N-terminal domain of the Atlantic sea lamprey corticoid receptor, showing its critical role in steroid-mediated transcriptional activation and promoter-specific regulation.

Regional Cell Atlas of Human Intestine Shapes Distinct Immune Surveillance

The paper creates a regional cell atlas of human intestine using single-cell RNA sequencing and spatial transcriptomics, revealing how microenvironment shapes immune surveillance and disease susceptibility.

Metabolic characteristics of taste differences under the soil and hydroponic cultures of sweet potato leaves by using non-targeted metabolomics

This study compares the metabolic profiles of sweet potato leaves grown in soil versus hydroponic systems to identify metabolites associated with taste quality differences.

Molecular mechanism of the Orai channel activation

The paper reports the crystal structure and cryo-EM reconstruction of a constitutively active Drosophila Orai mutant, revealing the molecular mechanism of channel activation and Ca2+ permeation.