Author

Y.-H. Lao

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

K. W. Leong· 4 shared S. He· 4 shared R. Tomer· 3 shared S. Chauhan· 3 shared B. Xu· 2 shared C. Xu· 2 shared C.-W. Chi· 2 shared E. Azizi· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersBioengineering

K. W. Leong

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Author profile →

4 papers

Recent·Most cited

Human vascular organoids with a mosaic AKT1 mutation recapitulate Proteus syndrome

S. He, Y. Zhu, S. Chauhan, D. N. Tavakol, J. H. Lee, R. B.-L. Berris, C. Xu, J. Lee, C. Lee, S. Cai, S. McElroy, G. Vunjak-Novakovic, R. Tomer, E. Azizi, B. Xu, , K. W. Leong

This paper creates a vascular organoid model with an AKT1 mutation to study Proteus syndrome and finds AKT inhibitors reverse vascular malformations.

bioRxiv · Jan 26, 2024 · PreprintBioengineering

Focused ultrasound-mediated brain genome editing

Y.-H. Lao, R. Ji, J. K. Zhou, K. J. Snow, N. Kwon, E. Saville, S. He, S. Chauhan, C.-W. Chi, M. S. Datta, H. Zhang, C. H. Quek, S. Cai, M. Li, Y. Gaitan, , K. W. Leong

This paper demonstrates a method to edit the brain genome in mammals using focused ultrasound to temporarily open the blood-brain barrier for CRISPR/Cas9 delivery via intravenous injection.

bioRxiv · Dec 10, 2022Bioengineering

An Immune Cell Recirculation-Enabled Microfluidic Array to Study Dynamic Immunotherapeutic Activity in Recapitulated Tumor Microenvironment

C.-W. Chi, Y.-H. Lao, A. H. R. Ahmed, S. He, T. Merghoub, K. W. Leong, S. Wang

The paper develops a microfluidic array to study immune cell interactions in a tumor microenvironment, showing that anti-PD-L1 treatment improves T cell infiltration and reduces cancer cell apoptosis.

bioRxiv · Sep 9, 2022 · PreprintBioengineering

Mapping morphological malformation to genetic dysfunction in blood vessel organoids with 22q11.2 Deletion Syndrome

S. He, C. Xu, Y.-H. Lao, S. Chauhan, Y. Xiao, M. J. Willner, Y. Jin, S. McElroy, S. Rao, J. Gogos, R. Tomer, E. Azizi, B. Xu, K. W. Leong

This study uses blood vessel organoids from 22q11.2 DS patients to link genetic dysfunction to vascular malformations through single-cell transcriptomics and imaging.

bioRxiv · Nov 17, 2021 · PreprintBioengineering