Discovery and characterization of cell-permeable inhibitors of Leishmania mexicana CLK1 using an in-cell target engagement assay
Carolina Moura Costa Catta‐Preta, Priscila Zonzini Ramos, Juliana B. T. Carnielli, Stanley N. S. Vasconcelos, Adam Dowle, Rebeka Cataldo de Oliveira Fanti, C.V. dos Reis, Adriano C. Coelho, Katlin B. Massirer, Jeremy Charles Mottram, Rafael M. Couñago
This paper identifies and validates cell-permeable inhibitors of Leishmania mexicana CLK1 using a BRET-based assay, showing WZ8040 effectively targets CLK1 with minimal host toxicity.
ACS Infectious Diseases · Sep 25, 2025Peer-reviewedCell Biology