An electrostatic repulsion model of centromere organisation
Caelan Bell, Lifeng Chen, Maria Julia Maristany, Claudia Blaukopf, Huabin Zhou, Jan Huertas, Jose Ignacio Perez Lopez, Christoph C. H. Langer, Thomas L. Steinacker, Nikki Schuette, Lynda K. Doolittle, Jorge R. Espinosa, Sy Redding, Rosana Collepardo‐Guevara, Michael K. Rosen, Daniel W. Gerlich
This study identifies electrostatic repulsion as the mechanism driving centromere positioning at the chromatin surface, independent of condensin or microtubules.
bioRxiv · Sep 1, 2025 · PreprintCell Biology