Author

Lynda K. Doolittle

Howard Hughes Medical Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:mechanistic / dynamical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Assay:cryo-EM· 1 Approach:deep learning· 1

Frequent Co-Authors

Michael K. RoseniD· 4 shared Huabin ZhouiD· 3 shared Jan HuertasiD· 3 shared Jorge R. EspinosaiD· 3 shared Maria Julia MaristanyiD· 3 shared Rosana Collepardo‐GuevaraiD· 3 shared Bryan A. GibsoniD· 2 shared Elizabeth VillaiD· 2 shared

Activity by Year

2025-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersBiophysics

Michael K. RosenORCID

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Author profile →

4 papers

Recent·Most cited

Multi-scale structure of chromatin condensates rationalizes phase separation and material properties

Huabin Zhou, Jan Huertas, Maria Julia Maristany, Kieran O. Russell, June Ho Hwang, Run-Wen Yao, Nirnay Samanta, Joshua Hutchings, Ramya Billur, Momoko Shiozaki, Xiaowei Zhao, Lynda K. Doolittle, Bryan A. Gibson, Andrea Soranno, Margot Riggi, , Michael K. Rosen

The paper investigates the structure of chromatin condensates across scales and shows how nucleosome arrangement and histone interactions influence their physical properties.

Science · Dec 4, 2025Peer-reviewedBiophysics

An electrostatic repulsion model of centromere organisation

Caelan Bell, Lifeng Chen, Maria Julia Maristany, Claudia Blaukopf, Huabin Zhou, Jan Huertas, Jose Ignacio Perez Lopez, Christoph C. H. Langer, Thomas L. Steinacker, Nikki Schuette, Lynda K. Doolittle, Jorge R. Espinosa, Sy Redding, Rosana Collepardo‐Guevara, Michael K. Rosen, Daniel W. Gerlich

This study identifies electrostatic repulsion as the mechanism driving centromere positioning at the chromatin surface, independent of condensin or microtubules.

bioRxiv · Sep 1, 2025 · PreprintCell Biology

Nucleosome Spacing Can Fine-Tune Higher Order Chromatin Assembly

Lifeng Chen, Maria Julia Maristany, Stephen E. Farr, Jinyue Luo, Bryan A. Gibson, Lynda K. Doolittle, Jorge R. Espinosa, Jan Huertas, Sy Redding, Rosana Collepardo‐Guevara, Michael K. Rosen

The paper shows that nucleosome spacing affects chromatin phase separation stability and dynamics through inter- and intramolecular stacking trade-offs.

Nature Communications · Jul 9, 2025Peer-reviewedBiophysics

Quantitative Spatial Analysis of Chromatin Biomolecular Condensates using Cryo-Electron Tomography

Huabin Zhou, Joshua Hutchings, Momoko Shiozaki, Xiaowei Zhao, Lynda K. Doolittle, Shixin Yang, Rui Yan, Nikki Jean, Margot Riggi, Zhiheng Yu, Elizabeth Villa, Michael K. Rosen

The paper develops methods to analyze chromatin condensates using cryo-electron tomography and deep learning, revealing nucleosome structures and interactions in both reconstituted and native systems.

Proceedings of the National Academy of Sciences · May 6, 2025Peer-reviewedBiophysics