Christoph C. H. Langer

The paper shows cohesin function is partitioned within the TAD hierarchy to form cohesion zones and enable sister-chromatid cohesion while preserving loop folding.

This study identifies electrostatic repulsion as the mechanism driving centromere positioning at the chromatin surface, independent of condensin or microtubules.

This study reveals how cohesin facilitates homology search during DNA repair by reshaping chromosome architecture through two distinct cohesin pools.

HiCognition enables visual exploration and hypothesis testing of 3D genomic structure by integrating 1D genomics profiles and machine learning.