Coordinated topoisomerase function shapes the fluoroquinolone response of Chlamydia trachomatis
Andrew Terrebonne, Caitlynn Diggs, Scot P. Ouellette, Leiqiong Gao, Yuk‐Ching Tse‐Dinh, Li Shen
This study shows that fluoroquinolone susceptibility in Chlamydia trachomatis depends on stage-specific DNA supercoiling levels, with treatment affecting growth and persistence through inhibition of DNA replication and gyrase activity.
Microbiology Spectrum · Aug 27, 2026Peer-reviewedMicrobiology