Author

Li Shen

Louisiana State UniversityORCID 0000-0001-9869-7317Unclaimed ORCID profile · follow to get notified of new preprints

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Li Shen4 papers · Shanghai Medical College of Fudan University

Biology Disciplines

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Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Organism:chicken / avian· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Andrew TerrebonneiD· 2 shared Caitlynn Diggs· 2 shared Scot P. OuelletteiD· 2 shared Yuk‐Ching Tse‐DinhiD· 2 shared Abigail R. Swoboda· 1 shared Amanda SantosiD· 1 shared Guangming ZhongiD· 1 shared Leiqiong Gao· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersMicrobiology

Andrew TerrebonneORCID

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2 papers

Recent·Most cited

MicrobiologyMicrobiology SpectrumPeer-reviewedAug 27, 2026

Coordinated topoisomerase function shapes the fluoroquinolone response of Chlamydia trachomatis

Andrew Terrebonne, Caitlynn Diggs, Scot P. Ouellette…·Li Shen

This study shows that fluoroquinolone susceptibility in Chlamydia trachomatis depends on stage-specific DNA supercoiling levels, with treatment affecting growth and persistence through inhibition of DNA replication and gyrase activity.

DOI 10.1128/spectrum.02206-26

chicken / avianDNA methylation

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Molecular BiologyJournal of BacteriologyPeer-reviewedAug 12, 2025

The SWIB domain-containing DNA topoisomerase I of Chlamydia trachomatis mediates DNA relaxation

Li Shen, Abigail R. Swoboda, Caitlynn Diggs…·Yuk‐Ching Tse‐Dinh

This study shows that Chlamydia trachomatis TopA, containing a SWIB domain, mediates DNA relaxation and is essential for bacterial growth and host interaction.

1 citation

bacteria (other)experimental assay

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