Guangming Zhong

This study identifies four coordinated transcriptional programs in Chlamydia trachomatis during its developmental cycle using time-course RNA sequencing.

This study shows type I and II interferons have distinct and overlapping roles in controlling Chlamydia trachomatis infection in the female genital tract, with type I acting earlier and type II later, and both critical for suppression at different stages and locations.

This study compares transcriptomic responses of Chlamydia trachomatis to different stressors, revealing distinct reprogramming and shared features across conditions.

This study identifies Collaborative Cross mouse strains susceptible to chlamydial induction of hydrosalpinx, revealing strain-specific differences in infection and pathology outcomes.

This study shows that chlamydial histones HctA and HctB are essential for transgenerational developmental fitness, as their deficiency during EB maturation impairs subsequent infection cycles.

This study shows that Chlamydia trachomatis TopA, containing a SWIB domain, mediates DNA relaxation and is essential for bacterial growth and host interaction.

This study identifies a dendritic cell-intrinsic TLR/MyD88/IL-23 pathway that promotes clearance of a live-attenuated oral vaccine in the large intestine.

The paper identifies a heat-induced negative feedback loop in Chlamydia involving HagF and HrcA that modulates chaperone gene expression and promotes infectious elementary body formation under stress.

The paper evaluates a pathogenicity-attenuated Chlamydia muridarum mutant, intrOv, showing it fails to establish productive infection at low doses but recovers similarly to wild-type by day 7.

This study shows that FtsK is essential for divisome assembly and septal peptidoglan synthesis in FtsZ-less Chlamydia trachomatis.

This study identifies Pgp2 as a plasmid replication initiator in Chlamydia, showing its beta-hairpin motif is essential for iteron-binding and plasmid replication.

The paper addresses challenges in differential expression analysis of Chlamydia RNA-Seq data by proposing normalization methods that better capture transcriptomic activation, validated through qRT-PCR.