Development of conditional-siRNA programmable riboswitch for targeting adverse cardiac remodeling
Priyanka Gokulnath, Ane Miren Salvador, Caleb Graham, Si‐ping Han, Guoping Li, Ramaswamy Kannappan, Christopher Azzam, Michail Spanos, Lisa J. Scherer, Palaniappan Sethu, John J. Rossi, William A. Goddard, Saumya Das
This paper develops a conditional-siRNA system that targets calcineurin in cardiac cells to reduce hypertrophy by responding to nppa mRNA, showing specific activation under stress conditions.
Molecular Therapy — Nucleic Acids · Aug 5, 2025Peer-reviewedMolecular Biology