A proteomic signature of vascular dysfunction linked to tauopathy and degeneration in the aging brain
Hannah L. Radabaugh, Jonah N. Keller, Caleb H. Radtke, Claudia Kunney, Nikolaos Karvelas, Harrison W. Chan, Nivetha Brathaban, Anke Meyer‐Franke, Kaitlin Blackstone Casaletto, Henrik Zetterberg, Bruce L. Miller, Carlos Cruchaga, Joel H. Kramer, Katerina Akassoglou, Adam R. Ferguson, Fanny M. Elahi
The paper identifies a proteomic signature linked to vascular dysfunction and neurodegeneration in aging brains, highlighting thromboinflammation as an early pathway to tauopathy.
bioRxiv · Oct 27, 2025 · PreprintNeuroscience