Alzheimer's disease induced neurons bearing PSEN1 mutations exhibit reduced excitability
Simon Maksour, Rocio K. Finol‐Urdaneta, Amy E. Hulme, Mauricio Castro Cabral-da-Silva, Helena Targa Dias Anastacio, Rachelle Balez, Tracey Berg, Calista Turner, Sonia Sanz Muñoz, Martin Engel, Predrag Kalajdzic, Leszek Lisowski, Kuldip Sidhu, Perminder Singh Sachdev, Mirella Dottori, Lezanne Ooi
This study investigates how PSEN1 mutations in Alzheimer's disease affect neuronal excitability using iPSC-derived neurons and finds reduced excitability and altered Kv/Nav channel currents in mutant neurons.
Frontiers in Cellular Neuroscience · Oct 9, 2024Peer-reviewedCell Biology