Martin Engel

This study investigates how PSEN1 mutations in Alzheimer's disease affect neuronal excitability using iPSC-derived neurons and finds reduced excitability and altered Kv/Nav channel currents in mutant neurons.

The paper introduces IL-VIS, a machine learning pipeline that incrementally learns and visualizes progression trajectories for longitudinal data, demonstrating its utility on brain organoid electrophysiological data.

The paper investigates REST and RCOR gene expression in human neurons and astrocytes using 2D and 3D stem cell models, finding cell-type-specific expression patterns.

This paper develops a 3D bioprinting platform using iPSC-derived CNS cells to create scalable, biomimetic cultures that support astrocyte growth, vasculogenesis, and enhanced neural differentiation.

This study identifies FDA-approved drugs that protect astrocytes in Vanishing White Matter Disease by targeting the integrated stress response and mitochondrial stress.