Perminder Singh Sachdev

Unified Multi-Cohort Harmonisation and Normative Modelling of Neuroimaging Data via Hierarchical GAMLSS

This paper introduces a hierarchical GAMLSS framework for harmonizing and modeling neuroimaging data across multiple cohorts, showing improved removal of cohort effects and preservation of biological signals.

Associations between volumes of grey matter regions and white matter hyperintensities with cognitive empathy in oldest-old adults

The paper examines associations between grey matter volumes and white matter hyperintensities with cognitive empathy measures in oldest-old adults, finding significant links between specific brain regions and different empathy assessment methods.

Identification of Circular RNAs associated with Ageing of the Dorsolateral Prefrontal Cortex across the Adult Lifespan

The paper identifies seven age-associated circRNAs in the dorsolateral prefrontal cortex across the adult lifespan, linked to synapse regulation and post-transcriptional networks.

Extreme conservation and rare evolutionary deviations in mammalian NOTCH3 inform the interpretation of CADASIL pathogenicity

The paper identifies rare NOTCH3 sequence variations across mammals and evaluates their structural and functional implications for CADASIL pathogenicity.

An Enhanced Conditional Variational Autoencoder-Based Normative Model for Neuroimaging Analysis

This paper introduces an enhanced cVAE-based normative model for neuroimaging data, showing comparable performance to existing methods while capturing individual deviations related to hypertension severity.

Alzheimer's disease induced neurons bearing PSEN1 mutations exhibit reduced excitability

This study investigates how PSEN1 mutations in Alzheimer's disease affect neuronal excitability using iPSC-derived neurons and finds reduced excitability and altered Kv/Nav channel currents in mutant neurons.

Brain-Age Prediction: Systematic Evaluation of Site Effects, and Sample Age Range and Size

The paper evaluates factors affecting brain-age prediction models using structural neuroimaging data from 35,683 individuals, finding optimal model performance with no site harmonization, age-binning, and a sample size of over 1,600.

Normative Modeling of Brain Morphometry Across the Lifespan using CentileBrain: Algorithm Benchmarking and Model Optimization

The paper benchmarks and optimizes a normative modeling framework for brain morphometry across the lifespan using MFPR, showing excellent accuracy and stability.

Polygenic resilience scores capture protective genetic effects for Alzheimers disease

This study identifies genetic resilience factors for Alzheimer's disease by constructing polygenic resilience scores that reduce genetic risk penetrance and correlate with polygenic risk scores in unaffected individuals.

Dissociable Cellular and Genetic Mechanisms of Cortical Thinning at Different Life Stages

The paper examines age-related variations in cortical thickness across different life stages using gene expression data from a large neuroimaging dataset.

Deep proteome analysis of plasma reveals novel biomarkers of mild cognitive impairment and Alzheimer's disease: A longitudinal study

Impact of APOE e3 and e4 genotypes on plasma proteome signatures in Alzheimer's disease

This study identifies plasma proteome differences associated with APOE e3 and e4 genotypes in Alzheimer's disease, revealing unique and shared molecular pathways involved in disease pathogenesis.

Brain structural covariances in the ageing brain in the UK Biobank

This study examines brain structural covariances in the ageing brain using UK Biobank data, finding age-related changes in cortical thickness and subcortical volume correlations, with sex differences and associations with cognition and longevity.

Age- and sex-related topological organisation of human brain functional networks and their relationship to cognition

The paper examines age and sex effects on brain network topology in older adults and links these to cognitive performance using UK Biobank data.

Novel genetic variants associated with brain functional networks in 18,445 adults from the UK Biobank

This study identifies genetic variants associated with brain functional network measures in UK Biobank participants, linking them to sleep and psychiatric traits.

Causes of variation in epigenetic aging across the lifespan

This study investigates the causes of variation in DNA methylation age across the lifespan, finding that environmental factors, particularly shared ones, are the main drivers.

Genetic and environmental determinants of variation in the plasma lipidome of older Australian twins

This study examines the heritability and environmental influences on the plasma lipidome in older Australian twins, finding most variation is due to unique environmental factors.

Age-related changes of Peak width Skeletonized Mean Diffusivity (PSMD) across the adult life span: a multi-cohort study

This study examines age-related changes in PSMD across the adult lifespan using multi-cohort diffusion tensor imaging data, finding PSMD increases consistently while other metrics show different age patterns.

Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

The paper reports epigenome-wide meta-analyses of blood DNA methylation with subcortical brain volumes, identifying significant associations with hippocampal volume and potential biological mechanisms.

Common genetic variation indicates separate etiologies for periventricular and deep white matter hyperintensities

This study identifies genetic loci specific to periventricular and deep white matter hyperintensities, revealing distinct genetic architectures and potential biological mechanisms.

Planar cell polarity pathway and development of the human visual cortex

The paper identifies genetic associations with cortical surface area using PCA and GWAS, linking DAAM1 to visual cortex development through mitochondrial pathways and thalamocortical input.

Differentiation of Alzheimer’s disease based on local and global parameters in personalized Virtual Brain models

This study uses personalized Virtual Brain models to show that local and global brain dynamics correlate with cognitive differences in Alzheimer’s disease and related conditions.

More Highly Myelinated White Matter Tracts are Associated with Faster Processing Speed in Healthy Adults

This study finds that myelin content in specific white matter tracts predicts processing speed in healthy adults, with age-related differences observed across tracts.

The independent influences of age and education on functional brain networks and cognition in healthy older adults

This study identifies three latent patterns linking age, education, and functional brain networks in healthy older adults, showing age affects core cognitive processes while education influences distinct networks.

An epigenome-wide association study of educational attainment (n = 10,767)

This study investigates the association between CpG methylation and educational attainment, finding limited significant associations that may be influenced by confounding factors.