BiochemistryACS CatalysisPeer-reviewed
Substrate scope and catalytic mechanism of α, β-epoxyketone synthase EpnF illuminated by in-situ esterase-mediated deprotection
Callum J Bullock, Marlene L. Rothe, Joshua W. Cartwright…·Gregory L. Challis
This paper develops an esterase-mediated strategy to generate unstable substrates for EpnF, revealing its broad substrate tolerance and catalytic mechanism for epoxyketone synthesis.
DOI 10.1021/acscatal.6c01175