The Rho effector ARHGAP18 coordinates a Hippo pathway feedback loop through YAP and Merlin to regulate the cytoskeleton and epithelial cell polarity.
Emma C. Murray, Gillian M. Hodge, Khanh Pham, Shane Fraher, Leighton S. Lee, Cameron A.R. Mitchell, Namya Manoj, Christine E. Schaner Tooley, Yongho Bae, Andrew T. Lombardo
This study identifies ARHGAP18 as a RhoA effector that forms a complex with YAP to coordinate Hippo and Rho pathways in regulating actin cytoskeleton and epithelial polarity.
Molecular Biology of the Cell · May 13, 2026Peer-reviewedCell Biology