Andrew T. Lombardo

This study identifies Myo9b's role in regulating epithelial brush border microvilli through RhoA signaling and shows that a disease variant disrupts microvilli formation in human cells.

This study identifies ARHGAP18 as a RhoA effector that forms a complex with YAP to coordinate Hippo and Rho pathways in regulating actin cytoskeleton and epithelial polarity.

This study reveals that ezrin activation involves spontaneous FERM-CTD dissociation triggered by PI(4,5)P2 binding, with phosphorylation stabilizing the open conformation.

This study shows survivin enhances VSMC migration in stiff environments, suggesting it could be a therapeutic target for arterial stiffness-related diseases.