Namya Manoj

Myosin-9b Controls Epithelial Brush Border Architecture through Motility-Dependent RhoA Signaling

This study identifies Myo9b's role in regulating epithelial brush border microvilli through RhoA signaling and shows that a disease variant disrupts microvilli formation in human cells.

Gliomas phenocopy an inborn error of metabolism to drive neuronal activity and tumor growth

This study identifies GAA accumulation in gliomas as a driver of neuronal activity and tumor growth, linking cancer metabolism to neuroscience through GABAA receptor activation.

The Rho effector ARHGAP18 coordinates a Hippo pathway feedback loop through YAP and Merlin to regulate the cytoskeleton and epithelial cell polarity.

This study identifies ARHGAP18 as a RhoA effector that forms a complex with YAP to coordinate Hippo and Rho pathways in regulating actin cytoskeleton and epithelial polarity.

Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice

The paper develops a platform to trace 30 nitrogen isotope-labeled metabolites, revealing cell state-specific pyrimidine synthesis pathway preferences in primitive and differentiated cells.

Pharmacological induction of mitochondrial stress counteracts therapy resistance in glioblastoma stem-like cells

This study shows that doxycycline induces mitochondrial stress and selectively kills glioblastoma stem-like cells, offering a drug repurposing strategy for therapy-resistant gliomas.