A functional map of phosphoprotein phosphatase regulation identifies an evolutionary conserved reductase for the catalytic metal ions
Bob Meeusen, Sara M. Ambjørn, Jiri Veis, Rachel C. Riley, Gianmatteo Vit, Brooke L. Brauer, Mads H. Møller, Elora C. Greiner, Camilla B. Chan, Melanie Bianca Weisser, Dimitriya Hristoforova Garvanska, Hao‐Jie Zhu, Norman E. Davey, Arminja Nadine Kettenbach, Egon Ogris, Jakob Nilsson
The paper identifies CYB5R4 as an evolutionarily conserved reductase that activates PP4 and PP6 by reducing their catalytic metal ions, essential for cell viability under oxidative stress.
bioRxiv · Feb 12, 2025 · PreprintCell Biology