Melanie Bianca Weisser

The paper identifies the SPATA5-SPATA5L1-CINP-C1ORF109 complex as essential for pre-60S ribosome maturation and shows its evolution from yeast Drg1.

The paper identifies CYB5R4 as an evolutionarily conserved reductase that activates PP4 and PP6 by reducing their catalytic metal ions, essential for cell viability under oxidative stress.

The paper identifies conserved mechanisms by which PP2A-B55 substrates bind B55 through α-helices and develops a competitive inhibitor to study its function.

This paper identifies VCF1 as a novel p97 cofactor that enhances p97-UFD1-NPL4 interactions with ubiquitylated substrates, promoting proteasomal degradation.

The paper identifies DAXX as a novel histone chaperone pathway that deposits H3.3K9me3 before DNA deposition, expanding the histone chaperone network's role in heterochromatin assembly.

This study traces the evolutionary origin of OCT4/POU5 functions in supporting pluripotency across vertebrates using sequence analysis and functional studies in mouse ESCs.

The paper determines the structure of a cytoplasmic pre-40S ribosomal subunit using cryo-EM, revealing conformational changes and the roles of assembly factors in its maturation.