Validating Conditionally Essential Targets: Discovery of the First Orally Effective Biotin Inhibitor against MycobacteriumTuberculosis
Qiang Liu, Joshua B. Wallach, Yahani P. Jayasinghe, Mark R. Sullivan, Julianna Proietto, Suyapa Rodriguez, Stephanie P. Vo, Helena I. Boshoff, Ziyi Jia, Camilla Folvar, Betelhem Tatek, Firat Kaya, Lev Ostrer, Kritee Mehdiratta, Rui Shi, , Courtney C. Aldrich
The paper develops an orally effective biotin inhibitor, C48, against Mycobacterium tuberculosis, demonstrating in vivo efficacy in a low-biotin mouse model.
bioRxiv · Sep 24, 2025 · PreprintMicrobiology