Author

Yahani P. Jayasinghe

Fred and Pamela Buffett Cancer CenterORCID 0000-0002-9313-8759Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Donald R. RonningiD· 2 shared Anthony D. BaughniD· 1 shared Betelhem Tatek· 1 shared Camilla Folvar· 1 shared Courtney C. AldrichiD· 1 shared Dirk SchnappingeriD· 1 shared Eric J. RubiniD· 1 shared Firat KayaiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersMicrobiology

Donald R. RonningORCID

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintSep 24, 2025

Validating Conditionally Essential Targets: Discovery of the First Orally Effective Biotin Inhibitor against MycobacteriumTuberculosis

Qiang Liu, Joshua B. Wallach, Yahani P. Jayasinghe…·Courtney C. Aldrich

The paper develops an orally effective biotin inhibitor, C48, against Mycobacterium tuberculosis, demonstrating in vivo efficacy in a low-biotin mouse model.

2 citations

mouseexperimental assay

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MicrobiologybioRxivPreprintAug 17, 2025

A D-alanine aminotransferase S180F substitution confers resistance to β-chloro-D-alanine in Staphylococcus aureus via antibiotic inactivation

Rakesh Roy, Yahani P. Jayasinghe, Sasmita Panda…·James P. O’Gara

This study identifies a S180F substitution in D-alanine aminotransferase (Dat) in Staphylococcus aureus that confers resistance to β-chloro-D-alanine by altering PLP co-factor binding and promoting antibiotic inactivation.

DOI 10.1101/2025.08.17.668425

humanexperimental assay

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