Author

Joshua B. Wallach

Weill Cornell Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:cell-cell communication· 1 Approach:contrastive learning· 1 Approach:deep learning· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

Dirk SchnappingeriD· 3 shared Helena I. BoshoffiD· 2 shared A. Paul Alivisatos· 1 shared Anthony D. BaughniD· 1 shared Artem SokoloviD· 1 shared Betelhem Tatek· 1 shared Bree B. AldridgeiD· 1 shared Camilla Folvar· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

Dirk SchnappingerORCID

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Author profile →

3 papers

Recent·Most cited

Identification and Evaluation of dibasic piperidines as novel cell wall inhibitors against Mycobacterium tuberculosis

Claire Naylor, Gareth A. Prosser, Tracy Bayliss, Lila Berle, Joshua B. Wallach, Heather Kim, Rodrigo Aguilera Olvera, Stephen Thompson, Thomas R. Ioerger, Laura Simpson, Ruth Casanueva, Laura Guijarro-López, K. R. Read, Paul Graham Wyatt, Dirk Schnappinger, , Laura A. T. Cleghorn

The paper identifies and evaluates dibasic piperidines as novel cell wall inhibitors against Mycobacterium tuberculosis, showing activity across multiple media and differential sensitivity in resistant strains.

ACS Infectious Diseases · May 14, 2026Peer-reviewedBiochemistry

Validating Conditionally Essential Targets: Discovery of the First Orally Effective Biotin Inhibitor against MycobacteriumTuberculosis

Qiang Liu, Joshua B. Wallach, Yahani P. Jayasinghe, Mark R. Sullivan, Julianna Proietto, Suyapa Rodriguez, Stephanie P. Vo, Helena I. Boshoff, Ziyi Jia, Camilla Folvar, Betelhem Tatek, Firat Kaya, Lev Ostrer, Kritee Mehdiratta, Rui Shi, , Courtney C. Aldrich

The paper develops an orally effective biotin inhibitor, C48, against Mycobacterium tuberculosis, demonstrating in vivo efficacy in a low-biotin mouse model.

bioRxiv · Sep 24, 2025 · PreprintMicrobiology

Integration of multi-modal measurements identifies critical mechanisms of tuberculosis drug action

William C. Johnson, A. Paul Alivisatos, Trever C. Smith, Nhi Van, Vijay Soni, Joshua B. Wallach, Nicholas A. Clark, Timothy A. Fitzgerald, Joshua J. Whiteley, Shumin Tan, Artem Sokolov, Dale Michael Ando, Dirk Schnappinger, Kyu Young Rhee, Bree B. Aldridge

This study introduces DECIPHAER, a tool that identifies critical mechanisms of tuberculosis drug action by integrating multi-modal data, revealing that respiration inhibition is more impactful than cell wall effects.

Cell Systems · Jul 29, 2025Peer-reviewedMicrobiology