An in vivo CRISPR screen unveils top target genes to improve CAR-T cell efficacy in a solid tumor model
Mattia Fumagalli, Dongjie An, Luca Simula, Camille Combe, Lisa Aziez, Yannick Simoni, Marie‐Clotilde Alves‐Guerra, Andrea Valentini, Maude Marchais, Anaïs Vermare, Josquin Moraly, Simona Manni, Maria Cecilia Quadraccia, Concetta Quintarelli, Biagio De Angelis, , Frédéric Pendino
This study uses an in vivo CRISPR screen to identify genes that enhance CAR-T cell efficacy in a solid tumor model, finding that disrupting REGNASE-1, SOCS1, PTPN2, and P16/NK4A improves tumor eradication.
Molecular Therapy · Apr 4, 2026Peer-reviewedImmunology