A single domain intrabody as a novel tool to bias the subcellular trafficking of the follicle-stimulating hormone receptor
Pauline Raynaud, Juliette Gourdon, Vinesh Jugnarain, Lucille Berthet, Frédéric Jean‐Alphonse, Océane Vaugrente, Camille Gauthier, Amandine Vallet, Priyanka Anujan, Delphine Naquin, Thomas Boulo, Christophe Gauthier, Danièle Klett, Yves Combarnous, Aylin Carla Hanyaloglu, , Pascale Crépieux
The paper describes a single domain intrabody, iPRC2, that biases the subcellular trafficking of the follicle-stimulating hormone receptor (FSHR) by rerouting it to early endosomes, reducing its surface recycling and cAMP production.
bioRxiv · Feb 13, 2025 · PreprintPharmacology & Toxicology