Pharmacology & ToxicologybioRxivPreprint
A single domain intrabody as a novel tool to bias the subcellular trafficking of the follicle-stimulating hormone receptor
Pauline Raynaud, Juliette Gourdon, Vinesh Jugnarain…·Pascale Crépieux
The paper describes a single domain intrabody, iPRC2, that biases the subcellular trafficking of the follicle-stimulating hormone receptor (FSHR) by rerouting it to early endosomes, reducing its surface recycling and cAMP production.