Frédéric Jean‐Alphonse

Spatiotemporal Modeling of GPCR Signaling: The Role of Endosomal Dynamics and Receptor Recycling

This study develops a mathematical framework integrating receptor trafficking and signaling compartmentalization to analyze how GPCR internalization and recycling affect ligand-induced responses.

LHR and Gαs trafficking drive sustained cAMP signalling from endosomes to control steroidogenesis

This study shows that LHR and Gαs trafficking from endosomes sustain cAMP signaling to control steroidogenesis in Leydig cells.

A single domain intrabody as a novel tool to bias the subcellular trafficking of the follicle-stimulating hormone receptor

The paper describes a single domain intrabody, iPRC2, that biases the subcellular trafficking of the follicle-stimulating hormone receptor (FSHR) by rerouting it to early endosomes, reducing its surface recycling and cAMP production.