Aylin Carla Hanyaloglu

This paper develops a fluorescent reporter system to detect PYY secretion from human enteroendocrine cells with single-event resolution, enabling drug discovery for metabolic diseases.

This study identifies D2R receptor mutants that stabilize oligomers and show biased recruitment of β-arrestin-2, leading to altered signaling outcomes.

This paper shows indole, a gut microbial metabolite, improves glucose control by boosting GLP-1 secretion and L-cell differentiation in mice, suggesting it could be used as a therapeutic for type 2 diabetes.

The paper shows butyrate activates FFAR2 in L-cells to increase PYY and Pax6, enhancing secretory function through a Gi-dependent pathway without receptor internalization.

This study shows that enteropancreatic neurons expressing NTSR1 mediate olive oil's effect on glucose tolerance by stimulating insulin release.

This study uses APEX2 proteomics to map the spatiotemporal interactome of the luteinizing hormone receptor (LHR) and identifies novel interactors like RAP2B that modulate receptor signaling and trafficking.

The paper describes a single domain intrabody, iPRC2, that biases the subcellular trafficking of the follicle-stimulating hormone receptor (FSHR) by rerouting it to early endosomes, reducing its surface recycling and cAMP production.

The paper shows that PGE2's spatial targeting to very early endosomes is crucial for coordinating cAMP signaling in decidualizing human endometrium.