This study develops a mathematical framework integrating receptor trafficking and signaling compartmentalization to analyze how GPCR internalization and recycling affect ligand-induced responses.

PLoS Computational Biology · Sep 29, 2026Peer-reviewedSystems Biology

A single domain intrabody as a novel tool to bias the subcellular trafficking of the follicle-stimulating hormone receptor

Pauline Raynaud, Juliette Gourdon, Vinesh Jugnarain, Lucille Berthet, Frédéric Jean‐Alphonse, Océane Vaugrente, Camille Gauthier, Amandine Vallet, Priyanka Anujan, Delphine Naquin, Thomas Boulo, Christophe Gauthier, Danièle Klett, Yves Combarnous, Aylin Carla Hanyaloglu, , Pascale Crépieux

The paper describes a single domain intrabody, iPRC2, that biases the subcellular trafficking of the follicle-stimulating hormone receptor (FSHR) by rerouting it to early endosomes, reducing its surface recycling and cAMP production.

bioRxiv · Feb 13, 2025 · PreprintPharmacology & Toxicology

Hormone-regulated dynamics of mRNA distribution on ribosomes in Sertoli cells

Xavier Leray, Julia Morales, Aurélie Trefier, Kelly E. Leon, Thomas Bourquard, Astrid Musnier, Emmanuel Pecnard, Lucile Drobecq, Sandrine Boulben, Nicolas Azzopardi, Rémi Coulaud, Hamza Ouchène, Yan Jaszczyszyn, Éric Reiter, Florian Guillou, , Pascale Crépieux

This study examines how FSH affects mRNA distribution on ribosomes in Sertoli cells, revealing that basal polysomal enrichment influences FSH-induced mRNA recruitment and protein function shifts.

bioRxiv · Dec 20, 2024 · PreprintSystems Biology